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Article

Establishment of an <i>oriP</i> Replicon Is Dependent upon an Infrequent, Epigenetic Event

1 Jul 2001

Abstract excerpt

Plasmids containing oriP, the latent origin of replication for Epstein-Barr virus, support efficient replication in selected cell clones when the viral protein EBNA-1 is provided, being lost at a rate of 2 to 4% per cell generation after removal of selection (A. L. Kirchmaier and B. Sugden, J. Virol. 69:1280-1283, 1995; B. Sugden and N. Warren, Mol. Biol. Med. 5:85-94, 1988). We refer to these plasmids as...

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Identifiers

PMID: 11390644
DOI: 10.1128/mcb.21.13.4149-4161.2001

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Establishment of an <i>oriP</i> Replicon Is Dependent upon an Infrequent, Epigenetic EventPMID 11390644Read ↗

Epstein-Barr virus-derived plasmids replicate only once per cell cycle and are not amplified after entry into cellsSemantic proximity Read ↗

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Plasmid maintenance of derivatives of oriP of Epstein-Barr virusSemantic proximity Read ↗

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The minimal replicator of Epstein-Barr virus oriP.Semantic proximity Read ↗

Maintenance of Epstein–Barr virus (EBV) <i>oriP</i> -based episomes requires EBV-encoded nuclear antigen-1 chromosome-binding domains, which can be replaced by high-mobility group-I or histone H1Semantic proximity Read ↗

Metaphase Chromosome Tethering Is Necessary for the DNA Synthesis and Maintenance of <i>oriP</i> Plasmids but Is Insufficient for Transcription Activation by Epstein-Barr Nuclear Antigen 1Semantic proximity Read ↗

Telomere Repeat Binding Factors TRF1, TRF2, and hRAP1 Modulate Replication of Epstein-Barr Virus OriPSemantic proximity Read ↗

EBNA1 can link the enhancer element to the initiator element of the Epstein-Barr virus plasmid origin of DNA replicationSemantic proximity Read ↗

Replication from <i>oriP</i> of Epstein-Barr Virus Requires Exact Spacing of Two Bound Dimers of EBNA1 Which Bend DNASemantic proximity Read ↗

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