Article
The minimal replicator of Epstein-Barr virus oriP.
Journal of virology - 1 May 2000
Yates J L, Camiolo S M, Bashaw J M
Abstract excerpt
oriP is a 1.7-kb region of the Epstein-Barr virus (EBV) chromosome that supports the replication and stable maintenance of plasmids in human cells. oriP contains two essential components, called the DS and the FR, both of which contain multiple binding sites for the EBV-encoded protein, EBNA-1. The DS appears to function as the replicator of oriP, while the FR acts in conjunction with EBNA-1 to prevent the loss...
Topics
- Base Sequence
- Binding Sites
- Cell Line
- DNA Replication
- Epstein-Barr Virus Nuclear Antigens
- Herpesvirus 4, Human
- Humans
- Manganese Compounds
- Molecular Sequence Data
- Mutation
- Oxides
- Plasmids