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Article

Initiation of DNA replication within oriP is dispensable for stable replication of the latent Epstein-Barr virus chromosome after infection of established cell lines.

Journal of virology - 1 Sept 2000

Norio P, Schildkraut C L, Yates J L

Abstract excerpt

The 165-kb circularized chromosome of Epstein-Barr virus (EBV) is replicated in latently infected cells once per cell cycle by host proteins during S phase. Replication initiates at multiple sites on latent EBV chromosomes, including within a 1.8-kb region called oriP, which can provide both replication and stabilization for recombinant plasmids in the presence of the EBV-encoded protein, EBNA-1. Replication...

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Source

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Identifiers

PMID: 10954558
DOI: 10.1128/jvi.74.18.8563-8574.2000
PMCID: PMC116369

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Initiation of DNA replication within oriP is dispensable for stable replication of the latent Epstein-Barr virus chromosome after infection of established cell lines.PMID 10954558Read ↗

Genetic evidence that EBNA-1 is needed for efficient, stable latent infection by Epstein-Barr virus.Semantic proximity Read ↗

Rep*: a viral element that can partially replace the origin of plasmid DNA synthesis of Epstein-Barr virus.Semantic proximity Read ↗

Sequence requirements of the Epstein-Barr virus latent origin of DNA replicationSemantic proximity Read ↗

Cell-cycle-dependent EBNA1-DNA crosslinking promotes replication termination at oriP and viral episome maintenance.Semantic proximity Read ↗

Replication from <i>oriP</i> of Epstein-Barr Virus Requires Exact Spacing of Two Bound Dimers of EBNA1 Which Bend DNASemantic proximity Read ↗

The minimal replicator of Epstein-Barr virus oriP.Semantic proximity Read ↗

Epstein-Barr virus-derived plasmids replicate only once per cell cycle and are not amplified after entry into cellsSemantic proximity Read ↗

The Amino Terminus of Epstein-Barr Virus (EBV) Nuclear Antigen 1 Contains AT Hooks That Facilitate the Replication and Partitioning of Latent EBV Genomes by Tethering Them to Cellular ChromosomesSemantic proximity Read ↗

The Linking Regions of EBNA1 Are Essential for Its Support of Replication and TranscriptionSemantic proximity Read ↗

Metaphase Chromosome Tethering Is Necessary for the DNA Synthesis and Maintenance of <i>oriP</i> Plasmids but Is Insufficient for Transcription Activation by Epstein-Barr Nuclear Antigen 1Semantic proximity Read ↗

oriP is essential for EBNA gene promoter activity in Epstein-Barr virus-immortalized lymphoblastoid cell linesSemantic proximity Read ↗

The Replisome Pausing Factor Timeless Is Required for Episomal Maintenance of Latent Epstein-Barr VirusSemantic proximity Read ↗

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