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Article

Sequence requirements of the Epstein-Barr virus latent origin of DNA replication

1 Mar 1994

Abstract excerpt

The Epstein-Barr virus (EBV) latent origin of DNA replication (oriP) is composed of two elements that contain binding sites for the sole viral gene product required for latent cycle replication, EBNA-1. One of these elements, region I, functions as an EBNA-1-dependent enhancer for RNA polymerase II-transcribed genes, may play a role in plasmid segregation, and is required for origin function in B cells latently...

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Identifiers

PMID: 8107251
DOI: 10.1128/jvi.68.3.1913-1925.1994

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Sequence requirements of the Epstein-Barr virus latent origin of DNA replicationPMID 8107251Read ↗

Initiation of DNA replication within oriP is dispensable for stable replication of the latent Epstein-Barr virus chromosome after infection of established cell lines.Semantic proximity Read ↗

Identification of EBNA1 amino acid sequences required for the interaction of the functional elements of the Epstein-Barr virus latent origin of DNA replicationSemantic proximity Read ↗

Genetic evidence that EBNA-1 is needed for efficient, stable latent infection by Epstein-Barr virus.Semantic proximity Read ↗

The Linking Regions of EBNA1 Are Essential for Its Support of Replication and TranscriptionSemantic proximity Read ↗

The minimal replicator of Epstein-Barr virus oriP.Semantic proximity Read ↗

Rep*: a viral element that can partially replace the origin of plasmid DNA synthesis of Epstein-Barr virus.Semantic proximity Read ↗

Replication from <i>oriP</i> of Epstein-Barr Virus Requires Exact Spacing of Two Bound Dimers of EBNA1 Which Bend DNASemantic proximity Read ↗

An EBNA-1-dependent enhancer acts from a distance of 10 kilobase pairs to increase expression of the Epstein-Barr virus LMP geneSemantic proximity Read ↗

The Amino Terminus of Epstein-Barr Virus (EBV) Nuclear Antigen 1 Contains AT Hooks That Facilitate the Replication and Partitioning of Latent EBV Genomes by Tethering Them to Cellular ChromosomesSemantic proximity Read ↗

oriP is essential for EBNA gene promoter activity in Epstein-Barr virus-immortalized lymphoblastoid cell linesSemantic proximity Read ↗

Cellular transcription factors recruit viral replication proteins to activate the Epstein–Barr virus origin of lytic DNA replication, oriLytSemantic proximity Read ↗

Cell-cycle-dependent EBNA1-DNA crosslinking promotes replication termination at oriP and viral episome maintenance.Semantic proximity Read ↗

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