Article
Ubiquitous transgenic expression of the IL-23 subunit p19 induces multiorgan inflammation, runting, infertility, and premature death.
Journal of immunology (Baltimore, Md. : 1950) - 15 Jun 2001
Wiekowski M T, Leach M W, Evans E W, Sullivan L, Chen S C, Vassileva G, Bazan J F, Gorman D M, Kastelein R A, Narula S, Lira S A
Abstract excerpt
p19, a molecule structurally related to IL-6, G-CSF, and the p35 subunit of IL-12, is a subunit of the recently discovered cytokine IL-23. Here we show that expression of p19 in multiple tissues of transgenic mice induced a striking phenotype characterized by runting, systemic inflammation, infertility, and death before 3 mo of age. Founder animals had infiltrates of lymphocytes and macrophages in skin, lung,...
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