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Article

Myeloproliferative disease in transgenic mice expressing P230 Bcr/Abl: longer disease latency, thrombocytosis, and mild leukocytosis.

Blood - 1 Jul 2003

Inokuchi Koiti, Dan Kazuo, Takatori Miyuki, Takahuji Hidemasa, Uchida Naoya, Inami Mitsuharu, Miyake Koichi, Honda Hiroaki, Hirai Hisamaru, Shimada Takashi

Abstract excerpt

P230 Bcr/Abl has been associated with indolent myeloproliferative disease (MPD). We generated transgenic mice expressing P230Bcr/Abl driven by the promoter of the long terminal repeat of the murine stem cell virus of the MSCV neo P230 BCR/ABL vector. Two founder mice exhibited mild granulocytosis and marked thrombocytosis and developed MPD. The disease of one founder mouse, no. 13, progressed to extramedullary...

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Source

Identifiers

PMID: 12623846
DOI: 10.1182/blood-2002-10-3182

Genes

BCR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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