Article
In vivo requirement for RecJ, ExoVII, ExoI, and ExoX in methyl-directed mismatch repair.
Proceedings of the National Academy of Sciences of the United States of America - 5 Jun 2001
Burdett V, Baitinger C, Viswanathan M, Lovett S T, Modrich P
Abstract excerpt
Biochemical studies with model DNA heteroduplexes have implicated RecJ exonuclease, exonuclease VII, exonuclease I, and exonuclease X in Escherichia coli methyl-directed mismatch correction. However, strains deficient in the four exonucleases display only a modest increase in mutation rate, raising questions concerning involvement of these activities in mismatch repair in vivo. The quadruple mutant deficient in...
Topics
- Bacterial Proteins
- Base Pair Mismatch
- Cold Temperature
- DNA Repair
- DNA Repair Enzymes
- DNA-Binding Proteins
- Endodeoxyribonucleases
- Escherichia coli Proteins
- Exodeoxyribonucleases
- Mutation