Article
Gene therapy via blockade of monocyte chemoattractant protein-1 for renal fibrosis.
Journal of the American Society of Nephrology : JASN - 1 Apr 2004
Wada Takashi, Furuichi Kengo, Sakai Norihiko, Iwata Yasunori, Kitagawa Kiyoki, Ishida Yuko, Kondo Toshikazu, Hashimoto Hiroyuki, Ishiwata Yoshiro, Mukaida Naofumi, Tomosugi Naohisa, Matsushima Kouji, Egashira Kensuke, Yokoyama Hitoshi
Abstract excerpt
Monocyte chemoattractant protein (MCP)-1, also termed monocyte chemotactic and activating factor (MCAF)/CCL2, plays an important role in progressive organ fibrosis. It was hypothesized that MCP-1, through its cognate receptor, CCR2, regulates the pathogenesis and is therapeutically of importance for renal fibrosis. To achieve this goal, the therapeutic efficacy and efficiency in renal fibrosis induced by a...
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