Article
In vivo transfection of genes for renin and angiotensinogen into the glomerular cells induced phenotypic change of the mesangial cells and glomerular sclerosis.
Biochemical and biophysical research communications - 17 Jan 1995
Arai M, Wada A, Isaka Y, Akagi Y, Sugiura T, Miyazaki M, Moriyama T, Kaneda Y, Naruse K, Naruse M
Abstract excerpt
Locally activated renin angiotensin system plays an important role in the progression of the glomerular diseases. In order to understand the local effect of overexpressed angiotensin II in the glomerulus in situ, we introduced human genes for renin and angiotensinogen into the rat kidney by hemagglutinating virus of Japan-liposome procedure. Three days after transfection human renin was detected in the glomeruli...
Topics
- Actins
- Angiotensinogen
- Animals
- Antibodies, Monoclonal
- Cattle
- Chickens
- Collagen
- Gene Expression
- Glomerular Mesangium
- Glomerulosclerosis, Focal Segmental