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MutHTP: mutations in human transmembrane proteins.

Bioinformatics (Oxford, England) - 1 Jul 2018

Kulandaisamy A, Binny Priya S, Sakthivel R, Tarnovskaya Svetlana, Bizin Ilya, Hönigschmid Peter, Frishman Dmitrij, Gromiha M Michael

Abstract excerpt

Motivation: Existing sources of experimental mutation data do not consider the structural environment of amino acid substitutions and distinguish between soluble and membrane proteins. They also suffer from a number of further limitations, including data redundancy, lack of disease classification, incompatible information content, and ambiguous annotations (e.g. the same mutation being annotated as disease and...

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PMID: 29401218
DOI: 10.1093/bioinformatics/bty054

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