Article
Mutations in c-kit gene exons 9 and 13 in gastrointestinal stromal tumors among Japanese.
Japanese journal of cancer research : Gann - 1 May 2001
Sakurai S, Oguni S, Hironaka M, Fukayama M, Morinaga S, Saito K
Abstract excerpt
Gain-of-function mutation in c-kit proto-oncogene exon 11 has been described in about 20 -- 50% of gastrointestinal stroma tumor (GIST). Recently, additional mutational hot-spots in exon 9 and exon 13 of the c-kit gene have been reported in GISTs without mutations of exon 11, but a subsequent report in a Western population indicated that only a small portion of GISTs (eight of 200 GISTs, 4%) showed mutations in...
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