Article
KIT Exon 9-Mutated Gastrointestinal Stromal Tumours: Biology and Treatment.
Chemotherapy - 1 Jan 2022
Napolitano Andrea, Thway Khin, Smith Myles J, Huang Paul H, Jones Robin L
Abstract excerpt
BACKGROUND: The majority of gastroinstestinal stromal tumours (GISTs) harbour oncogenic mutations in the gene encoding for the tyrosine kinase (TK) KIT. The most common mutations are found in exon 11, followed by mutations in exon 9. The latter mutations are associated more frequently with GISTs in extra-gastric locations and with a more aggressive clinical behaviour. SUMMARY: Here, we review the unique and often...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.