Article
Association between the oxidative polymorphism and early onset of Parkinson's disease.
Clinical pharmacology and therapeutics - 1 Mar 1995
Agúndez J A, Jiménez-Jiménez F J, Luengo A, Bernal M L, Molina J A, Ayuso L, Vázquez A, Parra J, Duarte J, Coria F
Abstract excerpt
The frequency of five cytochrome P450IID6 allelic variants was studied in deoxyribonucleic acid from 123 patients with Parkinson's disease and 150 healthy volunteers. This was achieved by the use of mutation-specific polymerase chain reaction and restriction fragment length polymorphism. The analyses of the CYP2D6 genotype revealed no evidence for a higher prevalence of poor metabolizers among patients with...
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