Article
Polymorphism of quinone-metabolizing enzymes and susceptibility to ozone-induced acute effects.
American journal of respiratory and critical care medicine - 1 May 2001
Bergamaschi E, De Palma G, Mozzoni P, Vanni S, Vettori M V, Broeckaert F, Bernard A, Mutti A
Abstract excerpt
The role of the genetic polymorphism of NAD(P)H:quinone oxidoreductase (NQO1) and glutathione-S-transferase micro-1 (GSTM1) in the responsiveness to O(3)-induced acute effects was investigated in 24 healthy nonsmokers performing 2-h bike rides at ambient O(3) varying from 32 to 103 ppb. Before and after rides, each subject performed spirometric tests and provided a blood sample for the measurement of the Clara...
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