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Article

Control of the proliferation versus meiotic development decision in the C. elegans germline through regulation of GLD-1 protein accumulation.

Development (Cambridge, England) - 1 Jan 2004

Hansen Dave, Wilson-Berry Laura, Dang Thanh, Schedl Tim

Abstract excerpt

Maintenance of the stem cell population in the C. elegans germline requires GLP-1/Notch signaling. We show that this signaling inhibits the accumulation of the RNA binding protein GLD-1. In a genetic screen to identify other genes involved in regulating GLD-1 activity, we identified mutations in the nos-3 gene, the protein product of which is similar to the Drosophila translational regulator Nanos. Our data...

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Identifiers

PMID: 14660440
DOI: 10.1242/dev.00916

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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