Article
Oestrogen receptors and microsatellite instability in colorectal carcinoma patients.
Cancer letters - 10 Jul 2001
Notarnicola M, Gristina R, Messa C, Cariola F, Fiorente P, Caruso M L, Gentile M, Di Leo A
Abstract excerpt
About 10-15% of sporadic colorectal cancers show microsatellite instability (MIN), a mutator phenotype of mismatch repair genes. It seems that oestrogens may inhibit the pathway to colorectal carcinoma which involves a mismatch repair deficiency. Oestrogen receptorial status was evaluated in the neoplastic tissue and uninvolved surrounding mucosa of 17 MIN-positive and 33 MIN-negative tumours using an...
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