Article
Arginine 120 of prostaglandin G/H synthase-1 is required for the inhibition by nonsteroidal anti-inflammatory drugs containing a carboxylic acid moiety.
The Journal of biological chemistry - 8 Dec 1995
Mancini J A, Riendeau D, Falgueyret J P, Vickers P J, O'Neill G P
Abstract excerpt
The therapeutic action of nonsteroidal anti-inflammatory drugs (NSAIDs) is exerted through the inhibition of prostaglandin G/H synthase (PGHS), which is expressed as two isoenzymes, termed PGHS-1 and PGHS-2. From the crystal structure of sheep PGHS-1, it has been proposed that the carboxylic acid...
Topics
- Animals
- Anti-Inflammatory Agents, Non-Steroidal
- Arachidonic Acid
- Arginine
- Base Sequence
- Cells, Cultured
- Cyclooxygenase Inhibitors
- Molecular Sequence Data
- Mutation
- Oxidation-Reduction
- Prostaglandin-Endoperoxide Synthases