Stress-Activated MAP Kinase Cascades in Cellular Senescence

Abstract excerpt

In response to progressive telomere shortening in successive cell divisions, normal somatic cells withdraw from the cell cycle and exhibit irreversible growth arrest. This state, called cellular senescence, is induced not only by telomere shortening but also by various physico-chemical stressors that induce DNA damage and chromatin disruption as well as by strong mitogenic signals. Because senescent cells never...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Telomeres, Telomerase, and Senescence