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Article

Significance of Cellular Senescence in Aging and Cancer

1 Jan 2009

Abstract excerpt

Cellular senescence is a mechanism that induces an irreversible growth arrest in all somatic cells. Senescent cells are metabolically active but lack the capacity to replicate. Evolutionary theories suggest that cellular senescence is related to the organismal decline occurring in aging organisms. Also, such theories describe senescence as an antagonistically pleiotropic process that can have beneficial or...

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PMID: 20057963
DOI: 10.4143/crt.2009.41.4.187

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