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Article

Effect of mutation and phosphorylation of type I keratins on their caspase-mediated degradation.

The Journal of biological chemistry - 20 Jul 2001

Ku N O, Omary M B

Abstract excerpt

Type I keratins K18 and K19 undergo caspase-mediated degradation during apoptosis. Two known K18 caspase cleavage sites are aspartates in the consensus sequences VEVDA and DALDS, located within the rod domain and tail domain, respectively. Several K14 (another type I keratin) mutations within the caspase cleavage motif have been described in patients with epidermolysis bullosa simplex. Here we use extensive...

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PMID: 11356849
DOI: 10.1074/jbc.M103315200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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