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Article

An autocrine/paracrine loop linking keratin 14 aggregates to tumor necrosis factor alpha-mediated cytotoxicity in a keratinocyte model of epidermolysis bullosa simplex.

The Journal of biological chemistry - 20 Feb 2004

Yoneda Kozo, Furukawa Tetsushi, Zheng Ya-Juan, Momoi Takashi, Izawa Ichiro, Inagaki Masaki, Manabe Motomu, Inagaki Nobuya

Abstract excerpt

Epidermolysis bullosa simplex (EBS) is a blistering cutaneous disease featuring protein aggregates. Here we investigate the molecular mechanisms linking protein aggregates to cell death in a cellular model of EBS in which HaCaT keratinocytes are transfected with plasmids expressing various mutant forms of keratin 14 (K14). In HaCaT cells, mutant K14 was found to form ubiquitinated protein aggregates that...

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PMID: 14660619
DOI: 10.1074/jbc.M307242200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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