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Article

A phenotype-driven ENU mutagenesis screen identifies novel alleles with functional roles in early mouse craniofacial development.

Genesis (New York, N.Y. : 2000) - 1 Apr 2011

Sandell Lisa L, Iulianella Angelo, Melton Kristin R, Lynn Megan, Walker Macie, Inman Kimberly E, Bhatt Shachi, Leroux-Berger Margot, Crawford Michelle, Jones Natalie C, Dennis Jennifer F, Trainor Paul A

Abstract excerpt

Proper craniofacial development begins during gastrulation and requires the coordinated integration of each germ layer tissue (ectoderm, mesoderm, and endoderm) and its derivatives in concert with the precise regulation of cell proliferation, migration, and differentiation. Neural crest cells, which are derived from ectoderm, are a migratory progenitor cell population that generates most of the cartilage, bone,...

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Identifiers

PMID: 21305688
DOI: 10.1002/dvg.20727
PMCID: PMC3374396

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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