Article
Effects of disrupting the polyketide synthase gene WdPKS1 in Wangiella [Exophiala] dermatitidis on melanin production and resistance to killing by antifungal compounds, enzymatic degradation, and extremes in temperature.
BMC microbiology - 19 Jun 2006
Paolo William F, Dadachova Ekaterina, Mandal Piyali, Casadevall Arturo, Szaniszlo Paul J, Nosanchuk Joshua D
Abstract excerpt
BACKGROUND: Wangiella dermatitidis is a human pathogenic fungus that is an etiologic agent of phaeohyphomycosis. W. dermatitidis produces a black pigment that has been identified as a dihydroxynaphthalene melanin and the production of this pigment is associated with its virulence. Cell wall pigmentation in W. dermatitidis depends on the WdPKS1 gene, which encodes a polyketide synthase required for generating the...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.