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Aspergillus fumigatus melanins: interference with the host endocytosis pathway and impact on virulence

1 Jan 2013

Abstract excerpt

The opportunistic human pathogenic fungus Aspergillus fumigatus produces at least two types of melanin, namely pyomelanin and dihydroxynaphthalene (DHN) melanin. Pyomelanin is produced during tyrosine catabolism via accumulation of homogentisic acid. Although pyomelanin protects the fungus against reactive oxygen species (ROS) and acts as a defense compound in response to cell wall stress, mutants deficient for...

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PMID: 23346079
DOI: 10.3389/fmicb.2012.00440

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