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Article

Biosynthesis and functions of melanin in Sporothrix schenckii.

Infection and immunity - 1 Jun 2000

Romero-Martinez R, Wheeler M, Guerrero-Plata A, Rico G, Torres-Guerrero H

Abstract excerpt

Sporothrix schenckii is a human pathogen that causes sporotrichosis, an important cutaneous mycosis with a worldwide distribution. It produces dark-brown conidia, which infect the host. We found that S. schenckii synthesizes melanin via the 1,8-dihydroxynaphthalene pentaketide pathway. Melanin biosynthesis in the wild type was inhibited by tricyclazole, and colonies of the fungus were reddish brown instead of...

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Identifiers

PMID: 10816530
DOI: 10.1128/IAI.68.6.3696-3703.2000
PMCID: PMC97661

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Source receipt: pubmed, retrieved 7 Sept 2026.

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