Article
Etk/Bmx activation modulates barrier function in epithelial cells.
American journal of physiology. Cell physiology - 1 Jun 2001
Hamm-Alvarez S F, Chang A, Wang Y, Jerdeva G, Lin H H, Kim K J, Ann D K
Abstract excerpt
Etk/Bmx is a member of the Tec family of cytoplasmic non-receptor tyrosine kinases known to express in epithelial cells. We demonstrate herein that Etk activation in stably Etk-transfected epithelial Pa-4 cells resulted in a consistently increased transepithelial resistance (TER). After 24 h of hypoxic (1% O(2)) exposure, the TER and equivalent active ion transport rate (I(eq)) were reduced to <5% of the normoxia...
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