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Article

A role for loss of p53 function in sensitivity of ovarian carcinoma cells to taxanes

1 Jan 2001

Abstract excerpt

Loss of p53 function has been linked to increased responsiveness to taxane treatment of ovarian carcinoma in clinical studies. We recently reported that the acquisition of cisplatin resistance in an ovarian carcinoma cell line (IGROV-1) was associated with mutation of p53 and collateral sensitivity to paclitaxel. The increased sensitivity to paclitaxel of the cisplatin-resistant subline appeared to be...

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PMID: 11340581
DOI: 10.1002/1097-0215(20010601)92:5<738::aid-ijc1249>3.0.co;2-2

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