Article
Cisplatin-resistant HeLa cells are resistant to apoptosis via p53-dependent and -independent pathways.
Japanese journal of cancer research : Gann - 1 Dec 1999
Minagawa Y, Kigawa J, Itamochi H, Kanamori Y, Shimada M, Takahashi M, Terakawa N
Abstract excerpt
Since HeLa cells possess very little functional p53 activity, they could be originally resistant to genotoxic stress-induced apoptosis. Therefore, it is likely that the drug-resistant cells derived from HeLa cells are more resistant to apoptosis. The aim of this study was to determine whether cis...
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