Article
Apoptosis as a determinant of tumor sensitivity to topotecan in human ovarian tumors: preclinical in vitro/in vivo studies.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 1997
Caserini C, Pratesi G, Tortoreto M, Bedogné B, Carenini N, Supino R, Perego P, Righetti S C, Zunino F
Abstract excerpt
Preclinical and clinical studies have documented the pharmacological interest in camptothecin derivatives in the treatment of resistant tumors. In particular, topotecan, a water-soluble derivative, exhibited promising activity in pretreated ovarian carcinoma. The present study investigated the pa...
Topics
- Animals
- Apoptosis
- Cell Survival
- Cisplatin
- Clone Cells
- DNA Damage
- DNA Repair
- Drug Resistance, Neoplasm
- Exons
- Female
- Genes, p53
- Humans
- Mice
- Mice, Nude
- Mutation
- Ovarian Neoplasms
- Topotecan
- Transplantation, Heterologous