Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Apoptosis as a determinant of tumor sensitivity to topotecan in human ovarian tumors: preclinical in vitro/in vivo studies.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 1997

Caserini C, Pratesi G, Tortoreto M, Bedogné B, Carenini N, Supino R, Perego P, Righetti S C, Zunino F

Abstract excerpt

Preclinical and clinical studies have documented the pharmacological interest in camptothecin derivatives in the treatment of resistant tumors. In particular, topotecan, a water-soluble derivative, exhibited promising activity in pretreated ovarian carcinoma. The present study investigated the pattern of tumor response in two human ovarian carcinoma xenografts and in their cisplatin-resistant sublines...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to Clone Cells

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Damage

Share to DNA Repair

Share to Genes, p53

Share to Mutation

Source

Identifiers

PMID: 9815771

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Apoptosis as a determinant of tumor sensitivity to topotecan in human ovarian tumors: preclinical in vitro/in vivo studies.PMID 9815771Read ↗

A role for loss of p53 function in sensitivity of ovarian carcinoma cells to taxanesSemantic proximity Read ↗

The Current Status of Camptothecin Analogues as Antitumor AgentsSemantic proximity Read ↗

Acquisition of chemoresistance in a human ovarian carcinoma cell line is linked to a defect in cell cycle controlSemantic proximity Read ↗

Topotecan (Hycamtin) responsiveness in human renal carcinoma cell lines of the clear cell and papillary types.Semantic proximity Read ↗

Deficient activation of CD95 (APO-1/Fas)-mediated apoptosis: a potential factor of multidrug resistance in human renal cell carcinoma.Semantic proximity Read ↗

Topotecan synergizes with CHEK1 (CHK1) inhibitor to induce apoptosis in ovarian cancer cellsSemantic proximity Read ↗

Cell-cycle progression and response of germ cell tumors to cisplatin in vitroSemantic proximity Read ↗

Topotecan in patients with BRCA-associated and sporadic platinum-resistant ovarian, fallopian tube, and primary peritoneal cancers.Semantic proximity Read ↗

Resistance to cisplatin does not affect sensitivity of human ovarian cancer cell lines to mifepristone cytotoxicitySemantic proximity Read ↗

Tracking the cell cycle origins for escape from topotecan action by breast cancer cellsSemantic proximity Read ↗

Expression of the anti-apoptotic gene survivin correlates with taxol resistance in human ovarian cancer.Semantic proximity Read ↗

Cell cycle changes associated with formation of Pt-DNA adducts in human ovarian carcinoma cells with different cisplatin sensitivitySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.