Article
Use of viral fusogenic membrane glycoproteins as novel therapeutic transgenes in gliomas.
Human gene therapy - 1 May 2001
Galanis E, Bateman A, Johnson K, Diaz R M, James C D, Vile R, Russell S J
Abstract excerpt
Malignant gliomas are the most common primary brain tumors in adults and, with few exceptions, have a dismal prognosis despite the therapeutic use of surgery, radiation therapy, and chemotherapy. Because CNS gliomas rarely metastasize, they represent an attractive target for gene therapy through local gene delivery. Here we report on the use of two different fusogenic membrane glycoproteins (FMGs), the measles...
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