Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Epidermal growth factor receptor (EGFR)-retargeted measles virus strains effectively target EGFR- or EGFRvIII expressing gliomas.

Molecular therapy : the journal of the American Society of Gene Therapy - 1 Apr 2007

Paraskevakou Georgia, Allen Cory, Nakamura Takafumi, Zollman Paula, James C David, Peng Kah Whye, Schroeder Mark, Russell Stephen J, Galanis Evanthia

Abstract excerpt

A retargeted measles virus strain MV-GFP-H(AA)-scEGFR was generated by engineering the MV-NSe Edmonston vaccine strain to incorporate both CD46 (Y481A) and signaling lymphocyte activation molecule (SLAM) (R533A) ablating mutations in the hemagglutinin protein in combination with the display of a single-chain antibody against epidermal growth factor receptor (EGFR) at the C terminus of hemagglutinin. The...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cricetulus
Share to Genes, erbB-1

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Engineering

Share to Measles virus

Share to Membrane Cofactor Protein

Share to Neoplasm Transplantation

Share to Transplantation, Heterologous

Share to Vero Cells

Source

Identifiers

PMID: 17299404
DOI: 10.1038/sj.mt.6300105

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Epidermal growth factor receptor (EGFR)-retargeted measles virus strains effectively target EGFR- or EGFRvIII expressing gliomas.PMID 17299404Read ↗

Virus-Based Therapies for the Treatment of Recurrent High-Grade GliomaSemantic proximity Read ↗

Attenuated multi–mutated herpes simplex virus–1 for the treatment of malignant gliomasSemantic proximity Read ↗

Advances and potential pitfalls of oncolytic viruses expressing immunomodulatory transgene therapy for malignant gliomasSemantic proximity Read ↗

Chimeric oncolytic adenovirus evades neutralizing antibodies from human patients and exhibits enhanced anti-glioma efficacy in immunized miceSemantic proximity Read ↗

A modified oncolytic measles virus exhibits strong immunotherapeutic potential through RIG-I activation by defective viral genomesSemantic proximity Read ↗

Specificity, Safety, Efficacy of EGFRvIII-Retargeted Oncolytic HSV for Xenotransplanted Human Glioblastoma.Semantic proximity Read ↗

Disabling a key viral innate immunity antagonist converts measles vaccine into RIG-I–driven cancer immunotherapySemantic proximity Read ↗

MicroRNA-sensitive Oncolytic Measles Viruses for Cancer-specific Vector TropismSemantic proximity Read ↗

Recombinant Measles Viruses Efficiently Entering Cells through Targeted ReceptorsSemantic proximity Read ↗

Dual Ligand Insertion in gB and gD of Oncolytic Herpes Simplex Viruses for Retargeting to a Producer Vero Cell Line and to Cancer CellsSemantic proximity Read ↗

The Epidermal Growth Factor Variant III Peptide Vaccine for Treatment of Malignant GliomasSemantic proximity Read ↗

Experimental Therapy of Human Glioma by Means of a Genetically Engineered Virus MutantSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.