Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Anatomical distribution and expression of CYP in humans: Neuropharmacological implications

2 Feb 2021

Abstract excerpt

The cytochrome P450 (CYP450) superfamily is responsible for the metabolism of most xenobiotics and pharmacological treatments generally used in clinical settings. Genetic factors as well as environmental determinants acting through fine epigenetic mechanisms modulate the expression of CYP over the lifespan (fetal vs. infancy vs. adult phases) and in diverse organs. In addition, pathological processes might alter...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Treatment and Pharmacology
Share to Drug Transport and Resistance Mechanisms
Share to Pharmacogenetics and Drug Metabolism

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 33533102
DOI: 10.1002/ddr.21778

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Anatomical distribution and expression of CYP in humans: Neuropharmacological implicationsPMID 33533102Read ↗

Drug-metabolizing cytochrome P450s in the brainSemantic proximity Read ↗

The Central Role of Cytochrome P450 in Xenobiotic Metabolism—A Brief Review on a Fascinating Enzyme FamilySemantic proximity Read ↗

Ontogeny of human hepatic cytochromes P450Semantic proximity Read ↗

Developmental expression of drug metabolizing enzymes: impact on disposition in neonates and young children.Semantic proximity Read ↗

Ontogeny of Hepatic Transporters and Drug-Metabolizing Enzymes in Humans and in Nonclinical SpeciesSemantic proximity Read ↗

The role of cytochrome P450 in developmental pharmacology.Semantic proximity Read ↗

Alternative splicing within the human cytochrome P450 superfamily with an emphasis on the brain: The convolution continues.Semantic proximity Read ↗

A Review of Developmental Aspects of Cytochrome P450Semantic proximity Read ↗

Profound changes in drug metabolism enzymes and possible effects on drug therapy in neonates and children.Semantic proximity Read ↗

Interindividual Variability in Cytochrome P450-Mediated Drug Metabolism.Semantic proximity Read ↗

Meta‐analysis of hepatic cytochrome P450 ontogeny to underwrite the prediction of pediatric pharmacokinetics using physiologically based pharmacokinetic modelingSemantic proximity Read ↗

Xenobiotic-induced transcriptional regulation of xenobiotic metabolizing enzymes of the cytochrome P450 superfamily in human extrahepatic tissues.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.