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Article

The secondary structure of the human immunodeficiency virus type 1 transcript modulates viral splicing and infectivity.

Journal of virology - 1 Aug 2008

Jablonski Joseph A, Buratti Emanuele, Stuani Cristiana, Caputi Massimo

Abstract excerpt

Splicing of human immunodeficiency virus type 1 (HIV-1) exon 6D is regulated by the presence of a complex splicing regulatory element (SRE) sequence that interacts with the splicing factors hnRNP H and SC35. In this work, we show that, in the context of the wild-type viral sequence, hnRNP H acts as a repressor of exon 6D inclusion independent of its binding to the SRE. However, hnRNP H binding to the SRE acts as...

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Identifiers

PMID: 18550660
DOI: 10.1128/JVI.00721-08
PMCID: PMC2519558

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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