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Structure Guided Design of Biotin Protein Ligase Inhibitors for Antibiotic Discovery

31 Dec 2013

Abstract excerpt

Biotin protein ligase (BPL) represents a promising target for the discovery of new antibacterial chemotherapeutics. Here we review the central role of BPL for the survival and virulence of clinically important Staphylococcus aureus in support of this claim. X-ray crystallography structures of BPLs in complex with ligands and small molecule inhibitors provide new insights into the mechanism of protein...

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PMID: 24236729
DOI: 10.2174/1568026613666131111103149

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