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Article

Coordinate control of sphingolipid biosynthesis and multidrug resistance in Saccharomyces cerevisiae.

The Journal of biological chemistry - 29 Jun 2001

Hallstrom T C, Lambert L, Schorling S, Balzi E, Goffeau A, Moye-Rowley W S

Abstract excerpt

Multiple or pleiotropic drug resistance often occurs in the yeast Saccharomyces cerevisiae through genetic activation of the Cys(6)-Zn(II) transcription factors Pdr1p and Pdr3p. Hyperactive alleles of these proteins cause overproduction of target genes that include drug efflux pumps, which in turn confer high level drug resistance. Here we provide evidence that both Pdr1p and Pdr3p act to regulate production of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 11323424
DOI: 10.1074/jbc.M101568200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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