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Article

Associations among telomerase activity, p53 protein overexpression, and genetic instability in lung cancer.

British journal of cancer - 1 May 1999

Wu X, Kemp B, Amos C I, Honn S E, Zhang W, Walsh G L, Spitz M R

Abstract excerpt

Genomic instability is a driving force for tumorigenesis. p53 and telomerase play central roles in maintaining genomic integrity. The purpose of this study was to assess the associations among p53 protein overexpression, telomerase activity and genetic instability in lung cancer. We found that telomerase activity was detectable in 80% of 100 lung tumours, but only 7.7% of 91 paired adjacent normal tissues. p53...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 10408853
DOI: 10.1038/sj.bjc.6690378
PMCID: PMC2362338

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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