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Article

A point mutation in a cadherin gene, Cdh23, causes deafness in a novel mutant, Waltzer mouse niigata.

Biochemical and biophysical research communications - 27 Apr 2001

Wada T, Wakabayashi Y, Takahashi S, Ushiki T, Kikkawa Y, Yonekawa H, Kominami R

Abstract excerpt

A novel mouse model for human nonsyndromic hearing loss, Waltzer niigata (v(ngt)), is found and subjected to positional cloning analysis. Genome-wide scan of 1648 backcross mice maps v(ngt) to the D10Mit258 locus near Waltzer (v). Recombination breakpoints are positioned on a physical map consist...

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Identifiers

PMID: 11322776
DOI: 10.1006/bbrc.2001.4724

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-11322776-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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A point mutation in a cadherin gene, Cdh23, causes deafness in a novel mutant, Waltzer mouse niigata.PMID 11322776Read ↗

Mutations in Cdh23 cause nonsyndromic hearing loss in waltzer mice.Semantic proximity Read ↗

Genomic structure, alternative splice forms and normal and mutant alleles of cadherin 23 (Cdh23).Semantic proximity Read ↗

Mutations in Cdh23, encoding a new type of cadherin, cause stereocilia disorganization in waltzer, the mouse model for Usher syndrome type 1D.Semantic proximity Read ↗

An ENU-induced mutation of Cdh23 causes congenital hearing loss, but no vestibular dysfunction, in mice.Semantic proximity Read ↗

Phenotypic differences in the inner ears of CBA/CaJ and C57BL/6J mice carrying missense and single base pair deletion mutations in the Cdh23 gene.Semantic proximity Read ↗

High-resolution genetic and physical mapping of modifier-of-deafwaddler (mdfw) and Waltzer (Cdh23v).Semantic proximity Read ↗

Compound heterozygosity of the functionally null Cdh23(v-ngt) and hypomorphic Cdh23(ahl) alleles leads to early-onset progressive hearing loss in mice.Semantic proximity Read ↗

Effects of Cdh23 single nucleotide substitutions on age-related hearing loss in C57BL/6 and 129S1/Sv mice and comparisons with congenic strains.Semantic proximity Read ↗

A new spontaneous mutation in the mouse Ames waltzer gene, Pcdh15.Semantic proximity Read ↗

Genetic variants of CDH23 associated with noise-induced hearing loss.Semantic proximity Read ↗

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Genetic mapping refines DFNB3 to 17p11.2, suggests multiple alleles of DFNB3, and supports homology to the mouse model shaker-2.Semantic proximity Read ↗

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