Article
Genetic mapping refines DFNB3 to 17p11.2, suggests multiple alleles of DFNB3, and supports homology to the mouse model shaker-2.
American journal of human genetics - 1 Apr 1998
Liang Y, Wang A, Probst F J, Arhya I N, Barber T D, Chen K S, Deshmukh D, Dolan D F, Hinnant J T, Carter L E, Jain P K, Lalwani A K, Li X C, Lupski J R, Moeljopawiro S, Morell R, Negrini C, Wilcox E R, Winata S, Camper S A, Friedman T B
Abstract excerpt
The nonsyndromic congenital recessive deafness gene, DFNB3, first identified in Bengkala, Bali, was mapped to a approximately 12-cM interval on chromosome 17. New short tandem repeats (STRs) and additional DNA samples were used to identify recombinants that constrain the DFNB3 interval to less, s...
Topics
- Alleles
- Animals
- Chromosome Mapping
- Chromosomes, Human, Pair 17
- Deafness
- Female
- Genetic Markers
- Haplotypes
- Humans
- Male
- Mice