Article
Genetic mapping refines DFNB3 to 17p11.2, suggests multiple alleles of DFNB3, and supports homology to the mouse model shaker-2.
American journal of human genetics - 1 Apr 1998
Liang Y, Wang A, Probst F J, Arhya I N, Barber T D, Chen K S, Deshmukh D, Dolan D F, Hinnant J T, Carter L E, Jain P K, Lalwani A K, Li X C, Lupski J R, Moeljopawiro S, Morell R, Negrini C, Wilcox E R, Winata S, Camper S A, Friedman T B
Abstract excerpt
The nonsyndromic congenital recessive deafness gene, DFNB3, first identified in Bengkala, Bali, was mapped to a approximately 12-cM interval on chromosome 17. New short tandem repeats (STRs) and additional DNA samples were used to identify recombinants that constrain the DFNB3 interval to less, similar6 cM on 17p11.2. Affected individuals from Bengkala and affected members of a family with hereditary deafness who...
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