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Article

High-resolution genetic and physical mapping of modifier-of-deafwaddler (mdfw) and Waltzer (Cdh23v).

Genomics - 1 May 2001

Bryda E C, Kim H J, Legare M E, Frankel W N, Noben-Trauth K

Abstract excerpt

Modifier-of-deafwaddler (mdfw) and waltzer (Cdh23v) are loci on mouse chromosome 10 encoding factors that are essential for the function of auditory hair cells. The BALB/cByJ-specific mdfw allele encodes a necessary and sufficient modifier that induces progressive early onset hearing loss in CBy-dfw2J heterozygotes. Recessive mutations in the waltzer locus result in circling behavior and congenital deafness. In...

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PMID: 11350126
DOI: 10.1006/geno.2001.6538

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