Article
Efficient in vitro and in vivo gene regulation of a retrovirally delivered pro-apoptotic factor under the control of the Drosophila HSP70 promoter.
Gene therapy - 1 Apr 2001
Romano G, Reiss K, Tu X, Peruzzi F, Belletti B, Wang J Y, Zanocco-Marani T, Baserga R
Abstract excerpt
We have developed a self-inactivating retroviral vector system with an internal, inducible Drosophila HSP70 promoter. This vector system delivers the desired transgene into cells rapidly and efficiently. It generates mixed populations of transduced cells where the transgene is inducible, and does not require the isolation of specific clones. Since the transgene is not expressed (or poorly expressed) at the...
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