Article
Regulation of toxin and bacteriocin gene expression in <i>Clostridium</i> by interchangeable RNA polymerase sigma factors
5 Apr 2006
Abstract excerpt
The production of major extracellular toxins by pathogenic strains of Clostridium botulinum, Clostridium tetani and Clostridium difficile, and a bacteriocin by Clostridium perfringens is dependent on a related group of RNA polymerase sigma-factors. These sigma-factors (BotR, TetR, TcdR and UviA) were shown to be sufficiently similar that they could substitute for one another in in vitro DNA binding and run-off...
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