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Biology and Molecular Epidemiology of Diphtheria Toxin and the<i>tox</i>Gene

1 Feb 2000

Abstract excerpt

Diphtheria toxin (DT) is an extracellular protein of Corynebacterium diphtheriae that inhibits protein synthesis and kills susceptible cells. The gene that encodes DT (tox) is present in some corynephages, and DT is only produced by C. diphtheriae isolates that harbor tox+ phages. The diphtheria toxin repressor (DtxR) is a global regulatory protein that uses Fe2+ as co-repressor. Holo-DtxR represses production of...

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Share to Clostridium difficile and Clostridium perfringens research
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PMID: 10657208
DOI: 10.1086/315554

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