Article
The DXD motif is required for GM2 synthase activity but is not critical for nucleotide binding.
Glycobiology - 1 Mar 2001
Li J, Rancour D M, Allende M L, Worth C A, Darling D S, Gilbert J B, Menon A K, Young W W
Abstract excerpt
We tested the importance of the aspartate-any residue-aspartate (DXD) motif for the enzymatic activity and nucleotide binding capacity of the Golgi glycosyltransferase GM2 synthase. We prepared point mutations of the motif, which is found in the sequence 352-VLWVDDDFV, and analyzed cells that sta...
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