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Article

A single valine to leucine switch disrupts Plasmodium falciparum AP2-G DNA binding and reveals GDV1's role in ap2-g activation.

Nature communications - 17 Jan 2026

Prajapati Surendra K, Dong Jeffrey X, Morahan Belinda J, Dotrang Thoai, Barbeau Michelle C, Williams April E, Hupalo Daniel, Wilkerson Matthew D, Dalgard Clifton L, Kafsack Bjorn F C, Llinás Manuel, Williamson Kim C

Abstract excerpt

Sexual commitment in Plasmodium parasites is essential for malaria transmission, yet the signaling events initiating sexual conversion in only a subpopulation of parasites remain unclear. We discovered a single valine(V2163) to leucine(L2163) mutation in a transcription factor required for P. falciparum gametocytogenesis (AP2-G) that abrogates sexual differentiation. AP2-G.L2163 does not bind the ap2-g consensus...

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DNA, Protozoan
Leucine
Mutation
Plasmodium falciparum
Protein Binding

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protozoan Proteins

Transcription Factors

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Identifiers

PMID: 41547993
DOI: 10.1038/s41467-026-68416-1
PMCID: PMC12913604

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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