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Article

Chloroquine-resistant Plasmodium falciparum isolates from the Sudan lack two mutations in the pfmdr1 gene thought to be associated with chloroquine resistance.

Transactions of the Royal Society of Tropical Medicine and Hygiene - 1 Jan 2000

Awad-el-Kariem F M, Miles M A, Warhurst D C

Abstract excerpt

Isolates of Plasmodium falciparum from 3 areas of the Sudan were recovered from cryopreservation in London and their chloroquine sensitivity was determined in vitro. Chloroquine resistance was detected in 6/6 isolates from Khartoum, 1/4 from Sennar and 3/3 from Gadarif, indicating that resistance is spreading. All the isolates were sensitive to mefloquine. Studies using blood spots on glass fibre discs and the...

Topics

Amino Acid Sequence
Animals
Chloroquine
Drug Resistance
Genes, Protozoan
Humans
In Vitro Techniques
Mefloquine
Molecular Sequence Data
Mutation
Plasmodium falciparum

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Polymerase Chain Reaction

Sudan

Source

Identifiers

PMID: 1287907
DOI: 10.1016/0035-9203(92)90140-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1287907-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Chloroquine-resistant Plasmodium falciparum isolates from the Sudan lack two mutations in the pfmdr1 gene thought to be associated with chloroquine resistance.PMID 1287907Read ↗

Cross sectional study to determine chloroquine resistance among Plasmodium falciparum clinical isolates from Khartoum, SudanSemantic proximity Read ↗

High-level chloroquine resistance in Sudanese isolates of Plasmodium falciparum is associated with mutations in the chloroquine resistance transporter gene pfcrt and the multidrug resistance Gene pfmdr1.Semantic proximity Read ↗

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