Article
A study of cytokine gene polymorphisms and protein secretion in renal transplantation.
Transplant immunology - 1 Feb 2001
Cartwright N H, Keen L J, Demaine A G, Hurlock N J, McGonigle R J, Rowe P A, Shaw J F, Szydlo R M, Kaminski E R
Abstract excerpt
Although there is evidence that cytokine gene polymorphisms are associated with varying quantities of cytokine protein production, the exact role of these polymorphisms in allograft rejection remains unclear. In a previous study, we demonstrated a significant association between high IL-10 secretion in mixed lymphocyte culture (MLC), together with HLA mismatching for at least 4-6 antigens, with the occurrence of...
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