Article
Robo2 is required for establishment of a precise glomerular map in the zebrafish olfactory system.
Development (Cambridge, England) - 1 Mar 2005
Miyasaka Nobuhiko, Sato Yuki, Yeo Sang-Yeob, Hutson Lara D, Chien Chi-Bin, Okamoto Hitoshi, Yoshihara Yoshihiro
Abstract excerpt
Olfactory sensory neurons (OSNs) expressing a given odorant receptor project their axons to specific glomeruli, creating a topographic odor map in the olfactory bulb (OB). The mechanisms underlying axonal pathfinding of OSNs to their precise targets are not fully understood. Here, we demonstrate that Robo2/Slit signaling functions to guide nascent olfactory axons to the OB primordium in zebrafish. robo2 is...
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