Article
A Gal4-sigma 54 hybrid protein that functions as a potent activator of RNA polymerase II transcription in yeast.
The Journal of biological chemistry - 29 Jun 2001
Chen B S, Sun Z W, Hampsey M
Abstract excerpt
The bacterial final sigma(54) protein associates with core RNA polymerase to form a holoenzyme complex that renders cognate promoters enhancer-dependent. Although unusual in bacteria, enhancer-dependent transcription is the paradigm in eukaryotes. Here we report that a fragment of Escherichia coli final sigma(54) encompassing amino acid residues 29-177 functions as a potent transcriptional activator in yeast when...
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