Article
Differential regulation of the rainbow trout (Oncorhynchus mykiss) MT-A gene by nuclear factor interleukin-6 and activator protein-1.
BMC molecular biology - 17 Dec 2013
Kling Peter, Modig Carina, Mujahed Huthayfa, Khalaf Hazem, von Hofsten Jonas, Olsson Per-Erik
Abstract excerpt
BACKGROUND: Previously we have identified a distal region of the rainbow trout (Oncorhynchus mykiss) metallothionein-A (rtMT-A) enhancer region, being essential for free radical activation of the rtMT-A gene. The distal promoter region included four activator protein 1 (AP1) cis-acting elements and a single nuclear factor interleukin-6 (NF-IL6) element. In the present study we used the rainbow trout hepatoma...
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