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Article

Regulation of retinoic acid-induced inhibition of AP-1 activity by orphan receptor chicken ovalbumin upstream promoter-transcription factor.

The Journal of biological chemistry - 14 Jun 2002

Lin Feng, Kolluri Siva Kumar, Chen Guo-quan, Zhang Xiao-kun

Abstract excerpt

Retinoids are therapeutically effective in the treatment of various cancers, and some of the therapeutic action of retinoids can be ascribed to their potent inhibition of AP-1 activity that regulates transcription of genes associated with cell growth. We recently reported that the expression of orphan receptor chicken ovalbumin upstream promoter-transcription factor (COUP-TF) plays a role in mediating the growth...

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PMID: 11934895
DOI: 10.1074/jbc.M201885200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Regulation of retinoic acid-induced inhibition of AP-1 activity by orphan receptor chicken ovalbumin upstream promoter-transcription factor.PMID 11934895Read ↗

Identification of COUP-TFII Orphan Nuclear Receptor as a Retinoic Acid–Activated ReceptorSemantic proximity Read ↗

Molecular mechanism of chicken ovalbumin upstream promoter-transcription factor (COUP-TF) actionsSemantic proximity Read ↗

The Chicken Ovalbumin Upstream Promoter-Transcription Factor II Negatively Regulates the Transactivation of Androgen Receptor in Prostate Cancer CellsSemantic proximity Read ↗

Retinoic acid receptors inhibit AP1 activation by regulating extracellular signal-regulated kinase and CBP recruitment to an AP1-responsive promoter.Semantic proximity Read ↗

Chicken Ovalbumin Upstream Promoter Transcription Factor (COUP-TF) Dimers Bind to Different GGTCA Response Elements, Allowing COUP-TF To Repress Hormonal Induction of the Vitamin D<sub>3</sub>, Thyroid Hormone, and Retinoic Acid ReceptorsSemantic proximity Read ↗

COUP-TFI and COUP-TFII regulate expression of the NHE through a nuclear hormone responsive element with enhancer activity.Semantic proximity Read ↗

Ubc9 interacts with chicken ovalbumin upstream promoter-transcription factor I and represses receptor-dependent transcription.Semantic proximity Read ↗

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The COUP-TFII variant lacking a DNA-binding domain inhibits the activation of the Cyp7a1 promoter through physical interaction with COUP-TFII.Semantic proximity Read ↗

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